What do you fix first, domes, timing or octane? LOL! Something is not happy & you need to get it fixed fast. It will start damaging other things, if it hasn't already.
If it was me, I would lower the compression. 500' is starting to stretch it out a little bit. We primarily run 1/4 mile & really notice a difference with the lower compressions.
If you are going to take the fuel route first, I would try C14 Plus.